49ers at Chiefs: Week 16 preview, odds and injuries

Week 16 · Sun, Dec 27 · Arrowhead Stadium4:25 PM ET

at4:25 PMET · CBS

At a glanceUpdated Nov 10, 2026, 7:08 PM ET

The San Francisco 49ers (7-1) visit the Kansas City Chiefs (6-2) on Sun, Dec 27, 4:25 PM ET at Arrowhead Stadium in Kansas City, MO (Week 16, 2026 season), on CBS.

When and where is 49ers vs Chiefs?

Sun, Dec 27, 4:25 PM ET at Arrowhead Stadium in Kansas City, MO. TV: CBS.

Who is injured for 49ers vs Chiefs?

49ers: Brandon Aiyuk (WR, out, personal), Deebo Samuel Sr. (WR, questionable, hamstring), Deommodore Lenoir (CB, questionable, foot), Mike Evans (WR, questionable, achilles) and Renardo Green (CB, questionable, back). Chiefs: Omarr Norman-Lott (DT, out, knee - acl), Jaylon Moore (OT, questionable, ankle), Mansoor Delane (CB, questionable, shoulder), Patrick Mahomes (QB, questionable, elbow), Peter Woods (DT, questionable, neck) and Xavier Worthy (WR, questionable, hamstring).

Cite this page

Pigskin Nightly, “49ers at Chiefs: Week 16 preview”, https://pigskinnightly.com/games/2026-12-27-sf-at-kc (updated 2026-11-11).

How we calculate Plain-text version Report an error

Regular season through week 15 · rank out of 32

Where this game will be decided

149ers pass protection vs Chiefs pass rush
The 49ers' pass protection ranks 1st in sack rate (3.1% sacked, 262 dropbacks) against a Chiefs pass rush ranked 31st (4.6% of dropbacks, 305 dropbacks faced).
1stSF offense30 spots apart31stKC defense

When the 49ers have the ballEdge SF · +9 ranks

SF dropback offenseEPA per dropbackKC pass defense

1st+0.31262 dropbacks

SF +9

-0.01 allowed305 dropbacks faced10th

SF run gameEPA per rushKC run defense

3rd+0.02205 rushes

-0.16 allowed197 rushes faced6th

Dropbacks include sacks and scrambles; rushes are designed runs. What EPA measures.

When the Chiefs have the ballNo big edge

KC dropback offenseEPA per dropbackSF pass defense

8th+0.16290 dropbacks

-0.01 allowed300 dropbacks faced11th

KC run gameEPA per rushSF run defense

2nd+0.09195 rushes

-0.18 allowed181 rushes faced1st

Third downEdge SF · +8 ranks

SF third-down offensethird-down conversion rateKC third-down defense

2nd52.3%88 third downs

SF +8

37.6% allowed109 third downs faced10th

KC third-down offensethird-down conversion rateSF third-down defense

12th42.1%95 third downs

40.8% allowed103 third downs faced17th

Conversions are third-down snaps that gained a first down or scored.

Red zoneNo big edge

SF red-zone offensered-zone touchdown rateKC red-zone defense

1st85%27 trips

38% allowed21 trips faced3rd

KC red-zone offensered-zone touchdown rateSF red-zone defense

10th63%30 trips

48% allowed25 trips faced8th

A trip is a drive with at least one snap inside the opponent's 20; the rate is trips that ended in an offensive touchdown. Small samples swing fast here.

Explosive playsNo big edge

SF big-play offenseexplosive-play rateKC defense against big plays

2nd12.6%467 plays

7.6% allowed502 plays faced7th

KC big-play offenseexplosive-play rateSF defense against big plays

4th10.9%485 plays

4.8% allowed481 plays faced1st

Completions of 20+ yards and runs of 10+, per snap. Definition.

Pressure & sacksEdge SF · +30 ranks

SF pass protectionsack rateKC pass rush

1st3.1% sacked262 dropbacks

SF +30

4.6% of dropbacks305 dropbacks faced31st

KC pass protectionsack rateSF pass rush

6th3.8% sacked290 dropbacks

KC +21

5.0% of dropbacks300 dropbacks faced27th

Sacks per dropback. The public play-by-play has no pressure charting, so this is the sack side of it only.

TurnoversNo big edge

SF ball securityturnovers per gameKC takeaway defense

16th1.1 giveaways a game8 games

1.3 takeaways a game8 games14th

KC ball securityturnovers per gameSF takeaway defense

5th0.8 giveaways a game8 games

1.4 takeaways a game8 games10th

Interceptions and lost fumbles on offensive snaps, per game. Turnover rates are among the least stable numbers in football.

AbsencesSF 0 · KC 0 regulars out or doubtful

49ers5 listed

0 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

QRenardo GreenCB97% defense · 8 wk
QDeommodore LenoirCB95% defense · 8 wk
QDeebo Samuel Sr.WR58% offense · 5 wk
QMike EvansWR54% offense · 6 wk
OUTBrandon AiyukWRno snaps

Chiefs6 listed

0 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

QPatrick MahomesQB99% offense · 8 wk
QJaylon MooreOT87% offense · 7 wk
QXavier WorthyWR83% offense · 8 wk
QMansoor DelaneCB79% defense · 5 wk
OUTOmarr Norman-LottDTno snaps
QPeter WoodsDTno snaps

Snap share is the average of the weeks each player was on the field this season. Full injury report ↓

Rest & travelSF +4 days of rest · SF travels 1,491 mi

Away49ers

10days since last game

1,491miles to get here

2time zones

Last: Thu wk 15 at LAC · Inglewood · 21,378 mi flown this season

2 time zones

Rest edge+4SF daysTravel gap 1,491 mi

HomeChiefs

6days since last game

0miles · home

0time zones

Last: Mon wk 15 vs NE · 8,895 mi flown this season

Normal week

League splits for these situations ↓

Sample: SF 8 games, 467 offensive and 481 defensive plays · KC 8 games, 485 offensive and 502 defensive plays. Rank 1 is the best offense or the best defense in each stat. Keys are the largest rank gaps (12+ spots) between an offense and the defense it faces, one per stat. Ranks are not schedule-adjusted.

Season to date · rank out of 32