# 49ers at Chiefs: Week 16 preview

> The San Francisco 49ers (7-1) visit the Kansas City Chiefs (6-2) on Sun, Dec 27, 4:25 PM ET at Arrowhead Stadium in Kansas City, MO (Week 16, 2026 season), on CBS.

- Source: https://pigskinnightly.com/games/2026-12-27-sf-at-kc
- Publisher: Pigskin Nightly (https://pigskinnightly.com)
- Updated: 2026-11-11T02:08:55.052Z
- Method: https://pigskinnightly.com/methodology
- Please cite as: Pigskin Nightly, "49ers at Chiefs: Week 16 preview", https://pigskinnightly.com/games/2026-12-27-sf-at-kc

## Questions and answers

### When and where is 49ers vs Chiefs?

Sun, Dec 27, 4:25 PM ET at Arrowhead Stadium in Kansas City, MO. TV: CBS.

### Who is injured for 49ers vs Chiefs?

49ers: Brandon Aiyuk (WR, out, personal), Deebo Samuel Sr. (WR, questionable, hamstring), Deommodore Lenoir (CB, questionable, foot), Mike Evans (WR, questionable, achilles) and Renardo Green (CB, questionable, back). Chiefs: Omarr Norman-Lott (DT, out, knee - acl), Jaylon Moore (OT, questionable, ankle), Mansoor Delane (CB, questionable, shoulder), Patrick Mahomes (QB, questionable, elbow), Peter Woods (DT, questionable, neck) and Xavier Worthy (WR, questionable, hamstring).