49ers at Cowboys: Week 10 preview, odds and injuries

Week 10 · Sun, Nov 15 · AT&T Stadium4:25 PM ET

at4:25 PMET · FoxSF -4.5 · O/U 55.5

At a glanceUpdated Nov 10, 2026, 4:57 PM ET

The San Francisco 49ers (7-1) visit the Dallas Cowboys (4-5) on Sun, Nov 15, 4:25 PM ET at AT&T Stadium in Arlington, TX (Week 10, 2026 season), on Fox. Betting line: SF -4.5, over/under 55.5.

When and where is 49ers vs Cowboys?

Sun, Nov 15, 4:25 PM ET at AT&T Stadium in Arlington, TX. TV: Fox.

Who is favored in 49ers vs Cowboys?

The line is SF -4.5 with an over/under of 55.5 (DraftKings).

Who is injured for 49ers vs Cowboys?

49ers: Brandon Aiyuk (WR, out, personal), Gracen Halton (DT, out, ankle), Deebo Samuel Sr. (WR, questionable, hamstring), Deommodore Lenoir (CB, questionable, foot), Mike Evans (WR, questionable, achilles) and Renardo Green (CB, questionable, back). Cowboys: Jake Ferguson (TE, out, knee), P.J. Locke (S, out, concussion), Tyler Goodson (RB, out, knee - acl + mcl), DeMarvion Overshown (LB, questionable, hamstring), Donovan Ezeiruaku (LB, questionable, ankle) and George Pickens (WR, questionable, hamstring) (plus 4 more).

Cite this page

Pigskin Nightly, “49ers at Cowboys: Week 10 preview”, https://pigskinnightly.com/games/2026-11-15-sf-at-dal (updated 2026-11-10).

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Regular season through week 9 · rank out of 32

Where this game will be decided

149ers dropback offense vs Cowboys pass defense
The 49ers' dropback offense ranks 1st in EPA per dropback (+0.31, 262 dropbacks) against a Cowboys pass defense ranked 28th (+0.17 allowed, 331 dropbacks faced).
1stSF offense27 spots apart28thDAL defense
249ers third-down offense vs Cowboys third-down defense
The 49ers' third-down offense ranks 2nd in third-down conversion rate (52.3%, 88 third downs) against a Cowboys third-down defense ranked 31st (50.0% allowed, 116 third downs faced).
2ndSF offense29 spots apart31stDAL defense
349ers run game vs Cowboys run defense
The 49ers' run game ranks 3rd in EPA per rush (+0.02, 205 rushes) against a Cowboys run defense ranked 27th (-0.02 allowed, 236 rushes faced).
3rdSF offense24 spots apart27thDAL defense

When the 49ers have the ballEdge SF · +27 ranks

SF dropback offenseEPA per dropbackDAL pass defense

1st+0.31262 dropbacks

SF +27

+0.17 allowed331 dropbacks faced28th

SF run gameEPA per rushDAL run defense

3rd+0.02205 rushes

SF +24

-0.02 allowed236 rushes faced27th

Dropbacks include sacks and scrambles; rushes are designed runs. What EPA measures.

When the Cowboys have the ballEdge SF · +8 ranks

DAL dropback offenseEPA per dropbackSF pass defense

9th+0.16371 dropbacks

-0.01 allowed300 dropbacks faced11th

DAL run gameEPA per rushSF run defense

9th-0.00214 rushes

SF +8

-0.18 allowed181 rushes faced1st

Third downEdge SF · +29 ranks

SF third-down offensethird-down conversion rateDAL third-down defense

2nd52.3%88 third downs

SF +29

50.0% allowed116 third downs faced31st

DAL third-down offensethird-down conversion rateSF third-down defense

3rd47.0%117 third downs

DAL +14

40.8% allowed103 third downs faced17th

Conversions are third-down snaps that gained a first down or scored.

Red zoneEdge SF · +24 ranks

SF red-zone offensered-zone touchdown rateDAL red-zone defense

1st85%27 trips

SF +24

69% allowed35 trips faced25th

DAL red-zone offensered-zone touchdown rateSF red-zone defense

3rd68%37 trips

48% allowed25 trips faced8th

A trip is a drive with at least one snap inside the opponent's 20; the rate is trips that ended in an offensive touchdown. Small samples swing fast here.

Explosive playsEdge SF · +22 ranks

SF big-play offenseexplosive-play rateDAL defense against big plays

2nd12.6%467 plays

SF +21

10.1% allowed567 plays faced23rd

DAL big-play offenseexplosive-play rateSF defense against big plays

23rd8.2%585 plays

SF +22

4.8% allowed481 plays faced1st

Completions of 20+ yards and runs of 10+, per snap. Definition.

Pressure & sacksEdge SF · +22 ranks

SF pass protectionsack rateDAL pass rush

1st3.1% sacked262 dropbacks

SF +22

5.1% of dropbacks331 dropbacks faced23rd

DAL pass protectionsack rateSF pass rush

5th3.8% sacked371 dropbacks

DAL +22

5.0% of dropbacks300 dropbacks faced27th

Sacks per dropback. The public play-by-play has no pressure charting, so this is the sack side of it only.

TurnoversEdge SF · +10 ranks

SF ball securityturnovers per gameDAL takeaway defense

16th1.1 giveaways a game8 games

SF +10

0.9 takeaways a game9 games26th

DAL ball securityturnovers per gameSF takeaway defense

8th0.9 giveaways a game9 games

1.4 takeaways a game8 games10th

Interceptions and lost fumbles on offensive snaps, per game. Turnover rates are among the least stable numbers in football.

AbsencesSF 0 · DAL 0 regulars out or doubtful

49ers6 listed

0 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

QRenardo GreenCB97% defense · 8 wk
QDeommodore LenoirCB95% defense · 8 wk
QDeebo Samuel Sr.WR58% offense · 5 wk
QMike EvansWR54% offense · 6 wk
OUTGracen HaltonDT44% defense · 8 wk
OUTBrandon AiyukWRno snaps

Cowboys10 listed

0 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

QGeorge PickensWR78% offense · 8 wk
QDeMarvion OvershownLB71% defense · 3 wk
QDonovan EzeiruakuLB65% defense · 9 wk
OUTJake FergusonTE56% offense · 9 wk
QJoey Porter Jr.CB54% defense · 4 wk
OUTP.J. LockeS49% defense · 4 wk
QJonathan MingoWR23% offense · 9 wk
OUTTyler GoodsonRB18% offense · 7 wk

Snap share is the average of the weeks each player was on the field this season. Full injury report ↓

Rest & travelSame rest · SF travels 1,438 mi

Away49ers

7days since last game

1,438miles to get here

2time zones

Last: Sun wk 9 vs LV (W 38-17) · 21,378 mi flown this season

2 time zones

Rest edgeEvensame restTravel gap 1,438 mi

HomeCowboys

7days since last game

0miles · home

0time zones

Last: Sun wk 9 at IND (W 27-23) · Indianapolis · 19,776 mi flown this season

Normal week

League splits for these situations ↓

Sample: SF 8 games, 467 offensive and 481 defensive plays · DAL 9 games, 585 offensive and 567 defensive plays. Rank 1 is the best offense or the best defense in each stat. Keys are the largest rank gaps (12+ spots) between an offense and the defense it faces, one per stat. Ranks are not schedule-adjusted.

Season to date · rank out of 32