Vikings at 49ers: Week 11 preview, odds and injuries

Week 11 · Sun, Nov 22 · Estadio Banorte8:20 PM ET

at8:20 PMET · NBCSF -3.5 · O/U 46.5

At a glanceUpdated Nov 10, 2026, 8:46 PM ET

The Minnesota Vikings (6-2) visit the San Francisco 49ers (7-1) on Sun, Nov 22, 8:20 PM ET at Estadio Banorte in Mexico City (Week 11, 2026 season), on NBC. Betting line: SF -3.5, over/under 46.5.

When and where is Vikings vs 49ers?

Sun, Nov 22, 8:20 PM ET at Estadio Banorte in Mexico City. TV: NBC.

Who is favored in Vikings vs 49ers?

The line is SF -3.5 with an over/under of 46.5 (DraftKings).

Who is injured for Vikings vs 49ers?

Vikings: Kyler Murray (QB, doubtful, hamstring), Jauan Jennings (WR, questionable, calf), Theo Jackson (S, questionable) and Tyrion Ingram-Dawkins (DE, questionable, ankle). 49ers: Brandon Aiyuk (WR, out, personal), Deebo Samuel Sr. (WR, questionable, hamstring), Deommodore Lenoir (CB, questionable, foot), Mike Evans (WR, questionable, achilles) and Renardo Green (CB, questionable, back).

Cite this page

Pigskin Nightly, “Vikings at 49ers: Week 11 preview”, https://pigskinnightly.com/games/2026-11-22-min-at-sf (updated 2026-11-11).

How we calculate Plain-text version Report an error

Regular season through week 10 · rank out of 32

Where this game will be decided

149ers run defense vs Vikings run game
The 49ers' run defense ranks 1st in EPA per rush (-0.18 allowed, 181 rushes faced) and faces a Vikings run game ranked 30th (-0.23, 181 rushes).
30thMIN offense29 spots apart1stSF defense
249ers defense against big plays vs Vikings big-play offense
The 49ers' defense against big plays ranks 1st in explosive-play rate (4.8% allowed, 481 plays faced) and faces a Vikings big-play offense ranked 19th (8.7%, 447 plays).
19thMIN offense18 spots apart1stSF defense
349ers pass defense vs Vikings dropback offense
The 49ers' pass defense ranks 11th in EPA per dropback (-0.01 allowed, 300 dropbacks faced) and faces a Vikings dropback offense ranked 27th (-0.11, 266 dropbacks).
27thMIN offense16 spots apart11thSF defense

When the Vikings have the ballEdge SF · +29 ranks

MIN dropback offenseEPA per dropbackSF pass defense

27th-0.11266 dropbacks

SF +16

-0.01 allowed300 dropbacks faced11th

MIN run gameEPA per rushSF run defense

30th-0.23181 rushes

SF +29

-0.18 allowed181 rushes faced1st

Dropbacks include sacks and scrambles; rushes are designed runs. What EPA measures.

When the 49ers have the ballEdge SF · +8 ranks

SF dropback offenseEPA per dropbackMIN pass defense

1st+0.31262 dropbacks

-0.18 allowed271 dropbacks faced1st

SF run gameEPA per rushMIN run defense

3rd+0.02205 rushes

SF +8

-0.11 allowed210 rushes faced11th

Third downEdge SF · +11 ranks

MIN third-down offensethird-down conversion rateSF third-down defense

28th35.2%105 third downs

SF +11

40.8% allowed103 third downs faced17th

SF third-down offensethird-down conversion rateMIN third-down defense

2nd52.3%88 third downs

32.4% allowed108 third downs faced2nd

Conversions are third-down snaps that gained a first down or scored.

Red zoneEdge SF · +17 ranks

MIN red-zone offensered-zone touchdown rateSF red-zone defense

25th50%18 trips

SF +17

48% allowed25 trips faced8th

SF red-zone offensered-zone touchdown rateMIN red-zone defense

1st85%27 trips

26% allowed19 trips faced1st

A trip is a drive with at least one snap inside the opponent's 20; the rate is trips that ended in an offensive touchdown. Small samples swing fast here.

Explosive playsEdge SF · +18 ranks

MIN big-play offenseexplosive-play rateSF defense against big plays

19th8.7%447 plays

SF +18

4.8% allowed481 plays faced1st

SF big-play offenseexplosive-play rateMIN defense against big plays

2nd12.6%467 plays

SF +9

8.7% allowed481 plays faced11th

Completions of 20+ yards and runs of 10+, per snap. Definition.

Pressure & sacksNo big edge

MIN pass protectionsack rateSF pass rush

26th8.6% sacked266 dropbacks

5.0% of dropbacks300 dropbacks faced27th

SF pass protectionsack rateMIN pass rush

1st3.1% sacked262 dropbacks

10.7% of dropbacks271 dropbacks faced1st

Sacks per dropback. The public play-by-play has no pressure charting, so this is the sack side of it only.

TurnoversEdge MIN · +11 ranks

MIN ball securityturnovers per gameSF takeaway defense

10th1.0 giveaways a game8 games

1.4 takeaways a game8 games10th

SF ball securityturnovers per gameMIN takeaway defense

16th1.1 giveaways a game8 games

MIN +11

1.5 takeaways a game8 games5th

Interceptions and lost fumbles on offensive snaps, per game. Turnover rates are among the least stable numbers in football.

AbsencesMIN 1 · SF 0 regulars out or doubtful

Vikings4 listed

1 of them is a regular ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

DKyler MurrayQB86% offense · 6 wk
QJauan JenningsWR67% offense · 6 wk
QTheo JacksonS59% defense · 7 wk
QTyrion Ingram-DawkinsDE59% defense · 8 wk

49ers5 listed

0 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

QRenardo GreenCB97% defense · 8 wk
QDeommodore LenoirCB95% defense · 8 wk
QDeebo Samuel Sr.WR58% offense · 5 wk
QMike EvansWR54% offense · 6 wk
OUTBrandon AiyukWRno snaps

Snap share is the average of the weeks each player was on the field this season. Full injury report ↓

Rest & travelSame rest · MIN travels 1,806 mi

AwayVikings

7days since last game

1,806miles to get here

0time zones

Last: Sun wk 10 at GB · Green Bay · 6,529 mi flown this season

Abroad · Mexico City

Rest edgeEvensame restTravel gap 52 mi

Designated home49ers

7days since last game

1,858miles to get here

2time zones

Last: Sun wk 10 at DAL · Arlington · 21,378 mi flown this season

Abroad · Mexico City2 time zones

League splits for these situations ↓

Sample: MIN 8 games, 447 offensive and 481 defensive plays · SF 8 games, 467 offensive and 481 defensive plays. Rank 1 is the best offense or the best defense in each stat. Keys are the largest rank gaps (12+ spots) between an offense and the defense it faces, one per stat. Ranks are not schedule-adjusted.

Season to date · rank out of 32