Seahawks at 49ers: Week 12 preview, odds and injuries

Week 12 · Sun, Nov 29 · Levi's Stadium4:25 PM ET

at4:25 PMET · Fox

At a glanceUpdated Nov 11, 2026, 4:03 AM ET

The Seattle Seahawks (5-4) visit the San Francisco 49ers (7-1) on Sun, Nov 29, 4:25 PM ET at Levi's Stadium in Santa Clara, CA (Week 12, 2026 season), on Fox.

When and where is Seahawks vs 49ers?

Sun, Nov 29, 4:25 PM ET at Levi's Stadium in Santa Clara, CA. TV: Fox.

Who is injured for Seahawks vs 49ers?

Seahawks: Sam Darnold (QB, out, quadriceps), Charles Cross (OT, doubtful, ankle), Quenton Nelson (G, doubtful, knee), Brandon Pili (DT, questionable, back), Drew Lock (QB, questionable, oblique) and Leonard Williams (DT, questionable, shoulder) (plus 2 more). 49ers: Brandon Aiyuk (WR, out, personal), Deebo Samuel Sr. (WR, questionable, hamstring), Deommodore Lenoir (CB, questionable, foot), Mike Evans (WR, questionable, achilles) and Renardo Green (CB, questionable, back).

Cite this page

Pigskin Nightly, “Seahawks at 49ers: Week 12 preview”, https://pigskinnightly.com/games/2026-11-29-sea-at-sf (updated 2026-11-11).

How we calculate Plain-text version Report an error

Regular season through week 11 · rank out of 32

Where this game will be decided

149ers red-zone offense vs Seahawks red-zone defense
The 49ers' red-zone offense ranks 1st in red-zone touchdown rate (85%, 27 trips) against a Seahawks red-zone defense ranked 32nd (79% allowed, 19 trips faced).
1stSF offense31 spots apart32ndSEA defenseSmall sample, read with care Why sample size matters
249ers run defense vs Seahawks run game
The 49ers' run defense ranks 1st in EPA per rush (-0.18 allowed, 181 rushes faced) and faces a Seahawks run game ranked 27th (-0.20, 241 rushes).
27thSEA offense26 spots apart1stSF defense
349ers defense against big plays vs Seahawks big-play offense
The 49ers' defense against big plays ranks 1st in explosive-play rate (4.8% allowed, 481 plays faced) and faces a Seahawks big-play offense ranked 22nd (8.4%, 559 plays).
22ndSEA offense21 spots apart1stSF defense

When the Seahawks have the ballEdge SF · +26 ranks

SEA dropback offenseEPA per dropbackSF pass defense

15th+0.08318 dropbacks

-0.01 allowed300 dropbacks faced11th

SEA run gameEPA per rushSF run defense

27th-0.20241 rushes

SF +26

-0.18 allowed181 rushes faced1st

Dropbacks include sacks and scrambles; rushes are designed runs. What EPA measures.

When the 49ers have the ballNo big edge

SF dropback offenseEPA per dropbackSEA pass defense

1st+0.31262 dropbacks

-0.09 allowed319 dropbacks faced4th

SF run gameEPA per rushSEA run defense

3rd+0.02205 rushes

-0.11 allowed207 rushes faced10th

Third downNo big edge

SEA third-down offensethird-down conversion rateSF third-down defense

17th38.6%114 third downs

40.8% allowed103 third downs faced17th

SF third-down offensethird-down conversion rateSEA third-down defense

2nd52.3%88 third downs

33.9% allowed121 third downs faced5th

Conversions are third-down snaps that gained a first down or scored.

Red zoneEdge SF · +31 ranks

SEA red-zone offensered-zone touchdown rateSF red-zone defense

22nd54%28 trips

SF +14

48% allowed25 trips faced8th

SF red-zone offensered-zone touchdown rateSEA red-zone defense

1st85%27 trips

SF +31

79% allowed19 trips faced32nd

A trip is a drive with at least one snap inside the opponent's 20; the rate is trips that ended in an offensive touchdown. Small samples swing fast here.

Explosive playsEdge SF · +21 ranks

SEA big-play offenseexplosive-play rateSF defense against big plays

22nd8.4%559 plays

SF +21

4.8% allowed481 plays faced1st

SF big-play offenseexplosive-play rateSEA defense against big plays

2nd12.6%467 plays

5.5% allowed526 plays faced2nd

Completions of 20+ yards and runs of 10+, per snap. Definition.

Pressure & sacksEdge SF · +12 ranks

SEA pass protectionsack rateSF pass rush

16th6.0% sacked318 dropbacks

SEA +11

5.0% of dropbacks300 dropbacks faced27th

SF pass protectionsack rateSEA pass rush

1st3.1% sacked262 dropbacks

SF +12

6.6% of dropbacks319 dropbacks faced13th

Sacks per dropback. The public play-by-play has no pressure charting, so this is the sack side of it only.

TurnoversEdge SF · +14 ranks

SEA ball securityturnovers per gameSF takeaway defense

24th1.6 giveaways a game9 games

SF +14

1.4 takeaways a game8 games10th

SF ball securityturnovers per gameSEA takeaway defense

16th1.1 giveaways a game8 games

1.2 takeaways a game9 games15th

Interceptions and lost fumbles on offensive snaps, per game. Turnover rates are among the least stable numbers in football.

AbsencesSEA 3 · SF 0 regulars out or doubtful

Seahawks8 listed

3 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

DQuenton NelsonG99% offense · 8 wk
DCharles CrossOT98% offense · 7 wk
QDrew LockQB97% offense · 3 wk
OUTSam DarnoldQB87% offense · 7 wk
QLeonard WilliamsDT72% defense · 8 wk
QUchenna NwosuLB51% defense · 7 wk
QRashid ShaheedWR50% offense · 7 wk
QBrandon PiliDT10% defense · 4 wk

49ers5 listed

0 of them are regulars ruled out or doubtful (60%+ of their unit's snaps across 3+ weeks on the field).

QRenardo GreenCB97% defense · 8 wk
QDeommodore LenoirCB95% defense · 8 wk
QDeebo Samuel Sr.WR58% offense · 5 wk
QMike EvansWR54% offense · 6 wk
OUTBrandon AiyukWRno snaps

Snap share is the average of the weeks each player was on the field this season. Full injury report ↓

Rest & travelSEA +7 days of rest · SEA travels 704 mi

AwaySeahawks

14days since last game

704miles to get here

0time zones

Last: Sun wk 10 at LV · Las Vegas · 8,902 mi flown this season

Off a bye

Rest edge+7SEA daysTravel gap 704 mi

Home49ers

7days since last game

0miles · home

0time zones

Last: Sun wk 11 vs MIN · Mexico City · 21,378 mi flown this season

Normal week

League splits for these situations ↓

Sample: SEA 9 games, 559 offensive and 526 defensive plays · SF 8 games, 467 offensive and 481 defensive plays. Rank 1 is the best offense or the best defense in each stat. Keys are the largest rank gaps (12+ spots) between an offense and the defense it faces, one per stat. Ranks are not schedule-adjusted.

Season to date · rank out of 32